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. 2014 May 6;2014:748524. doi: 10.1155/2014/748524

Figure 3.

Figure 3

Dox-induced impairment of autophagy in the heart. (a) Male 10–12 wk old WT mice (C57BL/6J) were treated with Dox as in Figure 1 for 4 days and then subjected to measurement of autophagic flux in the heart (n = 4 for each group). Upper panel: representative immunoblots as indicated. Lower panel: semiquantified analysis of LC3-II and p62 protein expression. *P < 0.05 versus Veh. (b) LV lysates as in Figure 2 were subjected to Western blot analysis of polyubiquitinated proteins (Ub-proteins). Upper panel: representative immunoblots as indicated. Lower panel: semiquantified analysis of Ub-proteins level. *P < 0.05 versus Veh in the same experimental group.