Table 1.

Exclusion Criteria

Deterioration to randomizable condition prior to admission to the participating hospital

Confluent parenchymal hematoma

Subdural hematoma

Subarachnoid hemorrhage

PTT > 40 seconds

INR > 1.4

Platelet count < 100 k/µL prior to correction with blood products

Pre-existing illness limiting life expectancy to less than 6 months

Pre-existing disability with modified Rankin > 2

Pre-existing or concurrent brain injury with associated deficits in addition to principal stroke

Current participation in another clinical trial