Table 2.
Patient treatment characteristics at recurrence.
| Parameters | Number of patients | Patients treated by Stupp protocol | Patients diagnosed with AA | Patients diagnosed with GBM |
|---|---|---|---|---|
| Numbers of patients | 87 | 51 | 41 | 46 |
| Gender Male Female |
43 (49.4%) 44 (50.6%) |
27 (52.9%) 24 (47.1%) |
16 (39%) 25 (61%) |
27 (58.7%) 19 (41.3%) |
| Age (years) median (range) |
48.7 (18–78) |
47 (26–71) |
45 (18–78) |
49.5 (26–78) |
| KPS Mean (range) KPS > 80 KPS ≤ 80 |
83 (60–100) 40 (46%) 47 (50%) |
90 (70–100) 28 (54.9%) 23 (45.1%) |
90 (70–100) 22 (53.7%) 19 (46.3%) |
80 (70–100) 18 (39.1%) 28 (60.9%) |
| RPA Mean (range) |
4.1 (3–5) |
4 (3–5) |
4 (3–5) |
4 (3–5) |
| Histology Anaplastic astrocytoma Glioblastoma |
41 (47.1%) 46 (52.9%) |
25 (49%) 26 (51%) |
100% 0 |
0 100% |
| Time to recurrence (months) Mean (range) ≤8 months 9–12 months >12 months |
13.8 (4–61) 29 (33.3%) 30 (34.5%) 28 (32.2%) |
11 (4–61) 14 (27.4%) 19 (27.3%) 18 (35.3%) |
10 (4–61) 12 (29.3%) 15 (36.6%) 14 (34.1%) |
10 (5–28) 17 (36.9%) 15 (32.6%) 13 (30.5%) |
| Tumour volume (cc) Mean (range) <3 cc 4–7 cc >7 cc |
8.7 (1–42.6) 29 (33.3%) 26 (29.9%) 32 (36.8%) |
4 (0.36–34.1) 16 (31.4%) 22 (43.1%) 13 (25.5%) |
5.2 (1–28) 12 (29.3%) 12 (29.3%) 17 (41.4%) |
4 (0.05–34.1) 17 (37%) 14 (30.4%) 15 (32.6%) |
| Location Unifocal Multifocal |
79 (90.8%) 8 (9.2%) |
45 (88.2%) 6 (11.8%) |
39 (95.1%) 2 (4.9%) |
40 (87%) 6 (13%) |
| Dose radiosurgery Mean (range) Dose ≥ 18 Gy |
18.01 Gy (14–20) 76 (87%) |
18 Gy (16–20) 46 (90.2%) |
18 (15–20) 35 (85.4%) |
18 Gy (14–20) 41 (89.1%) |
| PTV margin Mean (range) 0 mm 1–3 mm >3 mm |
1.67 mm (0–6) 43 (49.4%) 22 (25.3%) 22 (25.3%) |
2 mm (0–6) 20 (39.2%) 10 (19.6%) 21 (41.2%) |
2 mm (0–5) 19 (46.3%) 12 (29.3%) 10 (24.4%) |
0 mm (0–6) 24 (52.2%) 10 (21.7%) 12 (26.1%) |