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. 2013 Nov 27;65(12):3259–3270. doi: 10.1002/art.38184

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© 2013 The Authors. Arthritis & Rheumatism is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Muscle tissue inflammation in mice with the synaptotagmin VII (Syt VII) mutation is marked at 4 weeks but subsides over time. A, Muscle tissue inflammation in heterozygous (Syt VII^+/−) and mutant (Syt VII^−/−) mice. Mice were killed at the indicated times, and paraffin-embedded skeletal muscle tissue sections were stained with hematoxylin and eosin. All images were cropped for enhanced resolution and are representative of trends observed in at least 3 mice at each time point in independent experiments. Original magnification × 200. B, Extent of myositis in Syt VII^−/− mice at the 4-week time point, as determined by blinded histopathologic scoring. Values are the mean ± SD (n = 3 mice of each genotype). ∗ = P ≤ 0.05 versus Syt VII^+/−.