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. 2013 Nov 27;65(12):3259–3270. doi: 10.1002/art.38184

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© 2013 The Authors. Arthritis & Rheumatism is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Myositis is induced in RAG-1–null mouse recipients of FoxP3-deficient mouse lymph node cells exposed to muscle antigen. Lymph nodes from FoxP3-deficient mice were prepared and transferred by intraperitoneal injection, intramuscular (IM) injection, intraperitoneal coinjection with muscle tissue homogenate, or intraperitoneal coinjection with purified myosin protein. A, H&E-stained muscle tissue sections obtained from mice in the 4 treatment groups 4 weeks after adoptive transfer. Original magnification × 200. B, Results of digital image analysis showing the pixel intensity values for the inflammatory response induced by intraperitoneal and intramuscular injections. Values are the mean ± SD. C, Histopathologic scores of the H&E-stained muscle tissue sections, as determined by blinded analysis. Each symbol represents an individual mouse. Bars show the mean ± SD. Results are representative of trends observed in at least 3 mice (n = 2 individual experiments). ∗ = P < 0.05; ∗∗ = P < 0.01; ∗∗∗ = P < 0.005 versus intraperitoneal injection. See Figure 3 for other definitions.