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. 2013 Nov 27;65(12):3259–3270. doi: 10.1002/art.38184

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© 2013 The Authors. Arthritis & Rheumatism is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Inflammatory responses in myositis induced by exposure to muscle protein are predominated by CD4+ cells. Preparations of lymph node cells from FoxP3-deficient mice were adoptively transferred into recombination-activating gene 1–null recipients by intramuscular (IM) or intraperitoneal (IP) injection, with or without coadministration of muscle homogenate or purified myosin protein. A, Expression of CD4, CD8, F4/80, and B220 within inflammatory infiltrates, as determined by immunohistochemistry. Original magnification × 200. B, Results of digital image analysis showing the pixel intensity values in areas of infiltration for each leukocyte marker. Results are representative of similar trends observed in at least 5 mice (n = 4 independent experiments). Values are the mean ± SD. ∗ = P < 0.05; ∗∗ = P < 0.0001 versus all other markers in the same experimental group.