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. 2013 Nov 27;65(12):3259–3270. doi: 10.1002/art.38184

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© 2013 The Authors. Arthritis & Rheumatism is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Treg cells suppress immune-mediated muscle tissue inflammation. CD4+CD25+ Treg cells from wild-type C57BL/6 mice were isolated by immunomagnetic sorting, and the purity was confirmed by flow cytometry to be >80%. A and B, Representative hematoxylin and eosin–stained paraffin-embedded muscle tissue sections from recombination-activating gene 1–null mice that received intramuscular injections of lymph node cells from Foxp3-deficient mice (A) or intraperitoneal injections of lymph node cells from Foxp3/Syt VII double-mutant mice (B), either with or without CD4+CD25+ Treg cells. Original magnification × 200. C, Extent of inflammation induced by adoptive transfer, with and without Treg cell supplementation, as assessed quantitatively by digital image analysis and semiquantitatively by histopathologic scoring. Bars show the mean ± SD; values above the bars are the mean ± SD histopathologic scores (n = 3 independent experiments). ∗ = P < 0.001 versus no Treg cell supplementation.