Figure 6.

MMP9 activity is induced by lycopene in THP1 cells. THP1 cells were cultured for 12 h in the presence or not of lycopene (2 μM) together with or without different effectors acting specifically on the c-AMP metabolism (FSK, MDL, and IBMX). Culture medium was collected and zymography ((a), (b)) was performed as described under Materials and Methods. Densitometry analysis of zymograms (A) and (B) was performed and results are reported on graphs (c) and (d), respectively. One representative experiment out of three is shown.