Table 1.
Antimicrobial activity of compounds tested against different microorganisms (diameter of inhibition halo in mm).
| Microorganisms | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Synthetized compounds (300 µg/disc) |
Gram-positive bacteria | Gram-negative bacteria | Alcohol acid resistant bacteria | Yeast | ||||||
| n | Subs. |
S. aureus
DAUFPE 01 |
M. luteus
DAUFPE 06 |
E. faecalis
DAUFPE 138 |
B. subtilis
DAUFPE 16 |
P. aeruginosa
DAUFPE 39 |
E. coli
DAUFPE 224 |
S. marcescens
DAUFPE 398 |
M. smegmatis
DAUFPE 71 |
C. albicans
DAUFPE 1007 |
| 1 | — | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2a | 3-OCH3
4-OH |
19.3 ± 0.47 | 27.8 ± 0.16 | 11.2 ± 0.62 | 15.0 ± 0.16 | 15.0 ± 0.16 | 0 | 0 | 19.3 ± 0.77 | 16.2 ± 0.82 |
| 2b | 2,4-Cl | 11.7 ± 0.56 | 32.0 ± 0.81 | 18.8 ± 0.85 | 30.7 ± 0.47 | 0 | 0 | 0 | 19.2 ± 0.41 | 0 |
| 2c | 3,4-Cl | 19.4 ± 0.08 | 34.0 ± 0.80 | 8.4 ± 0.17 | 25.4 ± 0.05 | 0 | 0 | 0 | 12.1 ± 0.09 | 0 |
| 2d | 4-OH | 0 | 13.8 ± 0.56 | 11.0 ± 0.82 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2e | 3-OCH3 | 0 | 12.7 ± 0.56 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2f | 3-CH3 | 18.3 ± 0.47 | 0 | 18.8 ± 0.16 | 17.8 ± 0.62 | 0 | 0 | 0 | 0 | 0 |
| 2g | 3-NO2 | 21.8 ± 0.16 | 0 | 22.8 ± 0.70 | 23.7 ± 0.16 | 0 | 0 | 0 | 0 | 0 |
| 2h | 4-NO2 | 23.8 ± 0.16 | 0 | 21.9 ± 0.17 | 18.6 ± 0.15 | 0 | 0 | 0 | 0 | |
| 2i | 3-Cl | 20.8 ± 0.27 | 24.8 ± 0.16 | 21.8 ± 0.16 | 27.7 ± 0.16 | 0 | 0 | 0 | 0 | 0 |
|
| ||||||||||
| Kan (30 μg/disc) |
23.0 ± 0.82 | 28.3 ± 0.09 | 0 | 14.0 ± 0.82 | 20.0 ± 0.12 | 15.1 ± 0.19 | 15.0 ± 0.12 | 40.0 ± 0.12 | — | |
| Cef (30 μg/disc) |
35.3 ± 0.09 | 54.0 ± 0.12 | 24.1 ± 0.19 | 45.0 ± 0.12 | 0 | 24.3 ± 0.09 | 0 | 0 | — | |
| Ket (300 μg/disc) |
— | — | — | — | — | — | — | — | 24.1 ± 0.19 | |
Standard compounds: Cef: cephalexin; Ket: ketoconazole; Kan: kanamycin.
—: not tested; X: medium; δ: standard deviation.