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. 2014 Mar 28;66(4):960–968. doi: 10.1002/art.38315

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© 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Immunohistochemical detection of hyaluronan synthase 1 (HAS-1) in normal/reactive (A and C) and inflamed (B and D) synovial biopsy samples. Also shown are negative controls with normal goat IgG in normal/reactive (E) and inflamed (F) synovial biopsy samples. In inflamed synovial biopsy samples, there is an increase in HAS-1–positive cells with predominant localization in the intima lining. At the time of surgery, synovial biopsy samples from normal/reactive or inflamed areas were macroscopically selected as described in Patients and Methods. Normal/reactive and inflamed synovial biopsy samples were stained with anti–HAS-1 antibody. Representative images are shown. Arrows indicate intima lining. Original magnification × 5 in A and B; × 10 in C–F.