Table 1.
Genes differentially expressed between normal/reactive and inflamed areas of synovial biopsy samples*
| Pathway, type of compound | Up-regulated | Down-regulated |
|---|---|---|
| Inflammation | ||
| Cytokines | IL8 (4.45), IL6 (3.43), TNFRSF21 (1.99), IFI30 (1.91), TNFAIP6 (1.62), IRF8 (1.61) | – |
| Chemokines | CXCL5 (4.38), CXCL6 (3.89), CXCL16 (2.8), CXCL2 (2.62), CXCL1 (2.52) | – |
| Enzymes | ALOX5AP (3.35), PLD1 (2.64), ALOX5 (2.32), PTGES (2.04), PLCB1 (1.87), SOD2 (1.79), TBXAS1 (1.75), PI3 (1.71), PLA2G4A (1.58) | – |
| Other | TREM1 (3.45), S100A9 (2.68), OSM (1.57), PPARG (1.49) | – |
| Anabolism | HAS1 (2.16), BMP6 (2.48), COLL22A1 (2.05) | COL1A2 (0.75), VIM (0.75), MATN2 (0.74), HABP4 (0.72), HAPLN1 (0.66), HAS3 (0.65), COL16A1 (0.64), CILP (0.63), COL6A3 (0.63), GPC4 (0.58), HAPLN1 (0.58), ACAN (0.42) |
| Catabolism | MMP9 (3.53), MMP3 (2.82), CTSH (2.02), ADAMDEC1 (1.76), CTSS (1.52) | – |
| Angiogenesis | STC1 (5.83), PF4V1 (2.97), EDNRB (2.64), AQP9 (2.58), HBEGF (2.51), BDKRB1 (2.4), RCAN1 (2.31), ECGF1 (1.97), DNER (1.85), RCAN1 (1.84), BDKRB2 (1.7), PECAM1 (1.65) | PDGFC (0.71), RNH1 (0.69) |
*
Values in parentheses correspond to fold change of expression between normal/reactive and inflamed areas. Genes represented more than once (HAPLN1 and RCAN1) reflect different splice variants or transcript variants.