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. 2014 Mar 28;66(4):979–989. doi: 10.1002/art.38297

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© 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Simulation results showing the effect of interleukin-1 (IL-1) and/or oncostatin M (OSM) on the expression of matrix metalloproteinase 1 (MMP-1), MMP-13, and tissue inhibitor of metalloproteinases 1 (TIMP-1), using a simulated time period of 48 hours. Curves show the level of MMP-1 mRNA, MMP-13 mRNA, TIMP-1 mRNA, and collagen fragments. A, Effect of IL-1 alone. B, Effect of OSM alone. C, Effect of IL-1 plus OSM. Note that in B, MMP-1, MMP-13, and collagen levels are all zero; thus, the individual lines are not visible.