Figure 2.
Comparison of resting energy expenditure and selected plasma cytokines for HbAA and HbSS subjects. Values are mean ± SD, P values Mann-Whitney U Test. Group comparisons tests for resting energy expenditure (REE) and leptin were made after adjusting for significant predictors, fat-free mass (FFM) and fat mass (FM), respectively. MCP = monocyte chemoattractant protein, CRP = C-reactive protein, IL = interleukin. HbSS had significantly increased REE (P = 0.001), CPR (P < 0.001) and interleukin 6 (P = 0.013) compared with the HbAA. Leptin (P = 0.003), MCP-1 (P = 0.006) and interleukin-10 (P < 0.001) were significantly lower for the HbSS, whereas tumor necrosis factor-α, regulated upon activation, normal T-cell expressed and secreted (RANTES), and interleukin-1β, not shown, were not different across the groups.
