Skip to main content
. 2014 Apr 28;53(19):3229–3236. doi: 10.1021/bi500421q

Figure 2.

Figure 2

Etoposide quinone enhances DNA cleavage mediated by human topoisomerase IIβ. DNA cleavage was carried out in the presence of etoposide (Etop, red) or etoposide quinone (EQ, blue) in the absence (closed circles) or presence (open circles) of 50 μM dithiothreitol (DTT). The left panel shows drug titrations, and the right panel shows a time course for DNA cleavage in the presence of 15 μM etoposide quinone. Error bars represent the standard deviation of three or more independent experiments.