Figure 4.

Histogram of the relative errors generated by the human Y-family DNA polymerases as a function of template position. Lesion bypass analysis for (A and B) hPolη, (C and D) hPolκ, (E and F) hPolι, and (G and H) a combination of all 4 Y-family polymerases by using either the undamaged 17-mer/40-mer substrate or the damaged 17-mer/40-mer-8oxodG substrate. The relative number of base insertions (striped bar), substitutions (black bar), and deletions (white bar) as a percentage of the total dNTP incorporations are indicated at each template position. The template bases are denoted, and the 8-oxodG lesion is represented as “Y.” The indicated template positions are relative to the 8-oxodG lesion site within the 40-mer-8oxodG template.