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. 2014 Mar 12;9(5):1188–1196. doi: 10.1021/cb500071v

Figure 6.

Figure 6

InS3-54 inhibits the expression of STAT3 downstream target genes and STAT3 binding to chromatin. (A) Effect of inS3-54 on the expression of STAT3 downstream target genes in A549 and MDA-MB-231 cells. (B) Inhibition of IL-6 (25 ng/mL) stimulated STAT3 activation in serum-starved A549 cells. Actin was used as a loading control. (C, D) InS3-54 inhibition of STAT3 binding to chromatin in situ as determined using subcellular fractionation and Western blot analysis (C) or ChIP assay of Twist and cyclin D1 promoters (D).