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Cell death induced by Mcl-1 inhibitor 21 is Bax/Bak-dependent. MEFs deficient in Bax and Bak (gray bars) along with their wild-type counterpart (black bars) were exposed for 15 h to different concentrations of 21, and the cell viability was assessed with PI staining. Error bars represent the mean ± SEM. The significance was calculated using unpaired t test, and the number of data is shown for each tested concentration with corresponding significance: (**) p < 0.01 and (***) p < 0.001.
