Table 3.

Predictors of negative downstream tests and no events

	Univariate predictors (CI)	P-value	Multivariable model 1		Multivariable model 2
			Fit statistic	P-value	Fit statistic	P-value
Likelihood ratio χ2	–		61.49	<0.001	80.67	0.002*
ROC	–		0.7149	–	0.7451	0.018*
AIC	–		560.26	–	551.07	–
			Odds Ratio (CI)		Odds Ratio (CI)
Age (per 10 years)	0.67 (0.56 – 0.78)	<0.001	0.65 (0.54 – 0.78)	<0.001	0.72 (0.60 – 0.88)	0.001
Female gender	2.69 (1.81 – 4.01)	<0.001	2.89 (1.89 – 4.44)	<0.001	3.17 (2.00 – 5.01)	<0.001
≤ 1 risk factors†	1.00	reference	1.00	reference	1.00	reference
≥ 2 risk factors†	0.66 (0.42 – 1.01)	0.0564	0.59 (0.37 – 0.95)	0.030	0.65 (0.40 – 1.06)	0.087
Presenting symptoms
None	1.00	reference	1.00	reference	1.00	reference
Non-anginal chest pain	1.16 (0.74 – 1.81)	0.527	0.83 (0.51 – 1.35)	0.442	0.89 (0.54 – 1.48)	0.656
Atypical angina	0.65 (0.33 – 1.28)	0.216	0.52 (0.25 – 1.07)	0.079	0.62 (0.29 – 1.31)	0.209
Typical angina	0.53 (0.29 – 0.94)	0.029	0.40 (0.21 – 0.76)	0.005	0.50 (0.25 – 1.01)	0.052
ETT results
METs achieved (per METs)	1.08 (1.03 – 1.15)	0.005	–	–	1.09 (1.01–1.17)	0.037
Negative ETT	1.00	reference	–	–	1.00	reference
Typical Angina, -ECG	0.73 (0.35 – 1.52)	0.401	–	–	0.95 (0.40 – 2.26)	0.911
Rapid Recovery of ECG changes	3.64 (1.62 – 8.19)	0.002	–	–	2.67 (1.15 – 6.22)	0.013
Inconclusive for other reasons	1.06 (0.62 – 1.81)	0.832	–	–	1.32 (0.71 – 2.45)	0.380
Positive ETT	0.59 (0.33 – 1.06)	0.076	–	–	0.64 (0.34 – 1.21)	0.173

^*Comparing models 1 and 2;

^†Risk factors included hypertension, diabetes, dyslipidemia, current smoking, family history of premature CAD.

CI = confidence intervals