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. Author manuscript; available in PMC: 2014 May 26.
Published in final edited form as: Cell. 2013 Dec 19;155(7):1596–1609. doi: 10.1016/j.cell.2013.11.030

Figure 6. Microglia produce both pro and mature BDNF to phosphorylate neuronal TrkB.

Figure 6

(A) Neurons or microglia were cultured from P1 mice from BDNF-HA or WT animals. Cell lysates or culture media were immmunoprecipitated (IP) with a rabbit antibody to HA. Pro-BDNF and mature BDNF were detected by immunoblotting with a second antibody to HA (mouse HA1.1). (B) Synaptosome westerns for p-TrkB from CX3CR1CreER/+:BDNFflox/+ or CX3CR1CreER/+:BDNFflox/flox mice (*p<0.05, n=6). (C) Representative immunoblots of E18 rat neurons at DIV 8 treated as indicated. (D) Densitometric quantification of p-TrkB western blots in (C) (*p<0.05, **p<0.005, n=9). Data are represented as mean +/− SEM. See also Figure S6.