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. 2014 May 1;3:221. doi: 10.1186/2193-1801-3-221

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© Hara et al.; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Immunostaining of biopsied human liver tissues. (a, d) Liver biopsy samples from four patients (chronic hepatitis B and C virus infection [CH (B) and (C), respectively], AIH with severe fibrosis, and NASH. The hepatitis activity grade and fibrosis score are described in the upper corresponding micrograms. (b) Serial sections from CH(C) patient were stained with R58 and L59 antibodies. (c) Liver specimens from another CH(B) patient were stained with anti-αSMA, R58 antibodies. αSMA and R58 signal positive cells lined up along fibrous septa (yellow arrows). Scale bars = 50 μm.