Methods	Quasi-randomized, alternate allocation.
Participants	160 pregnant women who consulted in Simpson Memorial Maternity Pavilion from January, 1963 to April 1966 with bacteriological counts of 100,000/ml of urine were included
Interventions	Group 1:cycloserine 250 mg twice a day for 14 days. Group 2: sulphadimidine 500 mg 4 times a day for 14 days.
Outcomes	Primary outcomes: Symptomatic infection: group 1: 13/82; group 2:20/78. Persistent infection: group 1: 17/82; group 2: 39/78. Recurrent infection: group 1: 15/82; group 2: 16/78. Shift to another antibiotic: not reported. Adverse effects: Nausea: not reported. Headache: not reported. Flatulence: not reported. Others: not reported. Secondary outcomes: Preterm delivery: not compared between Cycloserine and Sulphadimidine Preterm labor: not reported. Neonatal infection: not reported. RDS in the neonate: not reported. Admission to NICU: not reported. Duration of neonatal respiratory support: not reported. Other outcomes: none.
Notes
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	No	Alternate allocation was used.
Allocation concealment?	No	Alternate allocation was used.
Blinding? Participant	No	1 antibiotic was given twice and day and the other was given 4 times a day
Blinding? Clinician	No	The 2 antibiotics were administered in different ways.
Blinding? Outcome assessor	Unclear	Not stated.
Incomplete outcome data addressed? All outcomes	No	There were 160 patients included in the part of the study that compared cycloserine and sulphadimidine. The results of all 160 patientswere accounted for. However, therewas also mention of 6 patients who were treated but withdrawn in the study. The results in these 6 patients were not available
Free of selective reporting?	Yes
Free of other bias?	Yes

cfu: colony-forming units

NICU: neonatal intensive care unit

NS: not specified

RCT: randomized controlled trial

RDS: respiratory distress syndrome

UTI: urinary tract infection