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. Author manuscript; available in PMC: 2014 May 27.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Sep 8;(9):CD007855. doi: 10.1002/14651858.CD007855.pub2

Comparison 3. 1-day nitrofurantoin versus 7-day nitrofurantoin.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Symptomatic infection 1 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
 1.1 Symptomatic infection at 2 weeks 1 741 Risk Ratio (M-H, Fixed, 95% CI) 0.71 [0.23, 2.22]
 1.2 Symptomatic infection prior to delivery 1 703 Risk Ratio (M-H, Fixed, 95% CI) 0.82 [0.36, 1.88]
2 Persistent infection 1 741 Risk Ratio (M-H, Fixed, 95% CI) 1.76 [1.29, 2.40]
3 Recurrent infection 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
4 Shift to another antibiotic 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
5 Adverse effect: nausea 1 760 Risk Ratio (M-H, Fixed, 95% CI) 0.72 [0.43, 1.20]
6 Adverse effect: vomiting 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
7 Adverse effect: diarrhea 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
8 Adverse effect: allergy or pruritus 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
9 Adverse effect: prematurely stopping treatment 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
10 Preterm delivery 1 703 Risk Ratio (M-H, Fixed, 95% CI) 1.24 [0.79, 1.94]
11 Preterm labor 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
12 Neonatal infection 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
13 Neonatal respiratory distress 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
14 Admission to the neonatal intensive care unit 0 0 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
15 Duration of neonatal ventilatory support 0 0 Mean Difference (IV, Fixed, 95% CI) Not estimable