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. 2014 May 26;205(4):541–554. doi: 10.1083/jcb.201307137

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© 2014 Matson and Stukenberg

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — Monastrol-treated cells do not retain Mad1 and Mad2 at anti-poleward kinetochores after CENP-I depletion. (A) Cartoon representation of kinetochore–microtubule attachments in Monastrol-treated cells. (B) Immunofluorescence images of cells after siRNA depletion and Monastrol treatment. Control cells retain Mad1 and Mad2 at anti-poleward kinetochores and recruit BubR1 to all kinetochores. CENP-I–depleted cells can still recruit BubR1 to kinetochores but fail to retain Mad1 and Mad2 at anti-poleward kinetochores. (C) Quantification of B. White arrows indicate select examples of anti-poleward facing kinetochores. Error bars indicate standard deviation. *, P < 0.005. Bars: (white) 5 µm; (yellow) 1 µm.