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. Author manuscript; available in PMC: 2014 May 27.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Jul 6;(7):CD009231. doi: 10.1002/14651858.CD009231
Methods RCT
Participants Requiring terminal care: treatment = 186 (87% with a diagnosis of cancer); control = 43 (86% with a diagnosis of cancer)
Living alone: treatment 21%, control 17%
Mean age: treatment 72 (SD 11); control 73 (SD 14)
Male 50%, female 54%
Survival from referral for both groups a median of 11 days

Interventions Referred from primary or secondary care
6 qualified nurses, 2 nursing aides, a co-ordinator (RGN level), agency staff providing 24-hour care if required for a maximum of 2 weeks, most had Marie Curie experience. Intervention patients could also access standard care
Control group received standard care: hospital care or hospice care, with input from the GP and district nurses, Marie Curie nursing, Macmillan nursing, social services and private nursing

Outcomes Symptoms and support, GP visits, place of death and admission to hospital

Notes UK study

Risk of bias

Bias Authors’ judgement Support for judgement

Random sequence generation (selection bias) Low risk 4:1 randomisation ratio (HAH:control) to ensure sufficient admissions to hospital at home. Random numbers from a random number table were used

Allocation concealment (selection bias) Low risk Allocation for each referral was assigned from a random number table by the researcher and concealed in sequentially numbered, opaque sealed envelopes

Blinding (performance bias and detection bias) High risk
All outcomes

Incomplete outcome data (attrition bias) Low risk Response rates: 144/198 (73%) for carers, 225/228 (99%) district nurses, 194/228 (85%) primary care physicians
All outcomes

Selective reporting (reporting bias) Low risk All stated outcomes reported

Baseline measures Low risk Demographic data

Protection against contamination High risk Intervention was contaminated by other input available to the control group (e.g. supplemented by GP and other community care when less than 24-hour hospital at home input was provided)