Figure 7. PDCA-1+ cell depletion reduces secretion of proinflammatory cytokines in infected 129S7 mice.
(a,b) 129S7 mice were treated with αPDCA-1 (filled triangles) or isotype control (open triangles) and infected with X31. Cytokine concentrations in BAL fluid were measured (a) by ELISA for IFNβ and λ and (b) by Multiplex for indicated cytokines. Graphs show mean±s.e.m. where n=2–3 and ***P<0.0001, **P<0.001, *P<0.01 by two-way ANOVA with Bonferroni post tests. The symbols on the right of graphs indicate statistical significance of the whole curve, as tested by two-way ANOVA.