Table 1.

Prognostic factors for BC metastatic to bone

Dimension, histotype, grading of primary tumor

Disease-free interval

First metastasis organs

Estrogen and progesterone receptor status, Her2

Resistance to systemic therapies

Solitary or multiple skeletal lesions

Type of lesions (mixed, lytic, sclerotic)

Skeletal localization

Asymptomatic or symptomatic bone disease (SREs)

Risk of pathological fracture (impending or complete)

Radiation sensitivity

Concomitant non-skeletal metastases

ECOG performance status (Karnofsky score)

Estimated life expectancy above or below 6 months