Table 2.
Characteristics of participants with Cryptococcal meningitis and controls with and without HIV
| Variable | HIV+ Cryptococcal Meningitis N=78 | HIV+ controls without meningitis N=110 | HIV− negative controls N=100 |
|---|---|---|---|
| Age | 35 (±8) | 36 (±9) | 31 (±7) |
| Males (N, %) | 48 (62%) | 31 (28%) | 47 (47%) |
| Years of Education | 8 (±4) | 9 (±5) | 10 (±4) |
| WHO Clinical Stage 4 (N, %) | 78 (100%) | 20 (18%) | -- |
| Clinical Factors at Baseline | |||
| Glasgow Coma Scale < 15 (N, %) | 19 (24%) | 0 (0%) | 0 (0%) |
| Karnofsky Score | 48 (±11) | 73 (±12) | 100 |
| Seizures (N, %) | 12 (15%) | -- | 0 (0%) |
| CD4+ T cells/μL | 40 (±69) | 176 (±191) | |
| HIV Viral Load, log10 copies/mL | 5.4 (±0.5) | ||
| CSF Profile at Cryptococcal Meningitis Diagnosis | |||
| Opening pressure, mmH2O | 301 (±140) | ||
| White blood cell count, cells/μL | 61 (±95) | ||
| C. neoformans quantitative culture, log10 CFU/mLa | 4.3 (±1.6) | ||
| Follow-up at 1 month | |||
| CES-D > 16 (N, %)b | 55 (72%) | ||
| Karnofsky Score | 61 (±10) | ||
| Int'l HIV Dementia Scale ≤10 (N, %)c | 71 (93%) | ||
Data presented are mean (± SD), unless otherwise noted.
a
Restricted to CSF specimens collected within 2 days of starting amphotericin, n=64
b
Center for Epidemiology Studies Depression Scale (CES-D) scores >16 suggest depression symptomatology, n=76
c
International HIV Dementia Scale ≤10 are suggestive of HIV dementia, n=77.