Figure 1.

Phyologenetic tree of the human P-type ATPases. Phylogenetic tree based on the core protein sequences of 137 animal homologues of the 36 human P-type ATPase isoforms. ATP13A2 homologues were obtained from the database Homologene http://www.ncbi.nlm.nih.gov/homologene. Core protein sequences were generated according to the methodology described in Axelsen and Palmgren (1998). The 36 human P-type ATPases are indicated. Of note, only animal isoforms are depicted, so the P3A-type ATPases, which are uniquely found in fungi and plants and the small class of bacterial Mg⁺-ATPases of the P3B group and bacterial pumps belonging to P1A are not represented. The phylogenetic tree was rendered using www.phylogeny.fr (Dereeper et al., 2008, 2010).