Table 4.
Olesoxime in brain and plasma after chronic administration to adult mice.
| Days of treatment | Dosemg/kg/d | Plasma levelsµg/mL | Brain levelsµg/g | Brain/plasma ratio |
|---|---|---|---|---|
| 7 | 0.3 | 0.06 ± 0.01 | BLQ | - |
| 3 | 0.55 ± 0.07 | 0.19 ± 0.02 | 0.35 | |
| 30 | 5.35 ± 1.19 | 1.23 ± 0.30 | 0.23 | |
| 42 | 0.3 | 0.06 ± 0.01 | BLQ | - |
| 3 | 0.47 ± 0.01 | 0.24 ± 0.04 | 0.51 | |
| 30 | 5.85 ± 1.06 | 2.66 ± 0.84 | 0.45 |
Olesoxime was administered by subcutaneous injection in Cremophore EL/DMSO/ethanol /Phosphate Buffer Saline (5/5/10/80 v/v). Tissue and plasma samples were collected 4 h following the last administration. Values are means ± SD (n = 3 mice). BLQ, below limit of quantification.