Table 2.
Favorable AED combinations | |
---|---|
CBZ | GBP [30]*& |
LEV [29] | |
OXC [29] | |
TPM [31] | |
VPA [32] | |
CZP | OXC [33] |
ESX | VPA [27,34]* |
FBM | LEV [35] |
LTG [36] | |
TPM [37]^& | |
GBP | LEV [38] |
LTG [30]* | |
OXC [39]^& | |
PB [30] | |
PHT [30] | |
TGB [40] | |
TPM [41] | |
VIG [42]^ | |
VPA [30]^& | |
LEV | CBZ [29] |
FBM [35] | |
OXC [29]^ | |
PB [25] | |
TPM [29]^ | |
LTG | FBM [36] |
GBP [30]* | |
TPM [43]*^& | |
VPA [43]*^& | |
OXC | CBZ [29] |
CZP [33] | |
GBP [39]^& | |
LEV [29]^ | |
TPM [37] | |
PB | GBP [30] |
LEV [25] | |
PHT [44]* | |
PHT | GBP [30] |
PB [44]* | |
VPA [31] | |
TGB | GBP [40] |
VIG [45]* | |
VPA [46] | |
TPM | CBZ [31] |
FBM^& | |
GBP [41] | |
LEV [29]^ | |
LTG [43]*^& | |
OXC [37] | |
VPA [31] | |
VIG | GBP [42]^ |
TGB [45]* | |
VPA | CBZ [32] |
ESX [27,34]* | |
GBP [30]^& | |
LTG [43]*^& | |
PHT [31] | |
TGB [46] | |
TPM [31] | |
Unfavorable AED combinations | |
CBZ | LTG [43] |
CZP | FBM [47] |
FBM | CBZ [47] |
OXC [37]! | |
TGB [39] | |
VPA [47] | |
LTG | CBZ [43]*! |
OXC [37]*! | |
OXC | FBM [37]! |
LTG [37] | |
PHT [33]! | |
PHT | OXC [33]! |
TGB | FBM [39] |
VPA | FBM [47] |
*: agreement with available human studies or case reports; ^: particularly favorable combinations; &: both synergy against seizures and antagonism for side effects (the most favorable);!: antagonism against seizures and synergy for side effects (the most unfavorable)