. 2010 Jul 26;3(8):2362–2379. doi: 10.3390/ph3082362

Table 2.

AED combinations determined by isobolographic studies in animals.

Favorable AED combinations
CBZ	GBP [30]*&
	LEV [29]
	OXC [29]
	TPM [31]
	VPA [32]
CZP	OXC [33]
ESX	VPA [27,34]*
FBM	LEV [35]
	LTG [36]
	TPM [37]^&
GBP	LEV [38]
	LTG [30]*
	OXC [39]^&
	PB [30]
	PHT [30]
	TGB [40]
	TPM [41]
	VIG [42]^
	VPA [30]^&
LEV	CBZ [29]
	FBM [35]
	OXC [29]^
	PB [25]
	TPM [29]^
LTG	FBM [36]
	GBP [30]*
	TPM [43]*^&
	VPA [43]*^&
OXC	CBZ [29]
	CZP [33]
	GBP [39]^&
	LEV [29]^
	TPM [37]
PB	GBP [30]
	LEV [25]
	PHT [44]*
PHT	GBP [30]
	PB [44]*
	VPA [31]
TGB	GBP [40]
	VIG [45]*
	VPA [46]
TPM	CBZ [31]
	FBM^&
	GBP [41]
	LEV [29]^
	LTG [43]*^&
	OXC [37]
	VPA [31]
VIG	GBP [42]^
VIG	TGB [45]*
VPA	CBZ [32]
	ESX [27,34]*
	GBP [30]^&
	LTG [43]*^&
	PHT [31]
	TGB [46]
	TPM [31]
Unfavorable AED combinations
CBZ	LTG [43]
CZP	FBM [47]
FBM	CBZ [47]
	OXC [37]!
	TGB [39]
	VPA [47]
LTG	CBZ [43]*!
LTG	OXC [37]*!
OXC	FBM [37]!
	LTG [37]
	PHT [33]!
PHT	OXC [33]!
TGB	FBM [39]
VPA	FBM [47]

*: agreement with available human studies or case reports; ^: particularly favorable combinations; &: both synergy against seizures and antagonism for side effects (the most favorable);!: antagonism against seizures and synergy for side effects (the most unfavorable)