Figure 2.

Catalytic and regulatory domains of the smooth muscle Ca²⁺-sensitizing protein kinases ROCK, ILK and ZIPK. The domains of human ROCK, ZIPK and ILK are identified by the starting and ending residues. Regulatory phosphorylation sites reported in the literature have been marked. Abbreviations: For ROCK: RBD, Rho-binding domain; PH, pleckstrin homology domain; C1, protein kinase C conserved region. For ZIPK: PSD, pseudosubstrate domain; LZ, leucine zipper domain. For ILK: AK, ankyrin repeat; PH, pleckstrin homology domain.