Table 3.
Comparative trials with NSAIDs in migraine attacks.
| Trial | Drug | N° patients | Results: |
|---|---|---|---|
| Geraud et al., 2002 [107] | ASA 900+Met 10 / Zolmi 2,5 | 666 | 2 h relief: ASA + Met (32.9%) = Zol (33.4%) |
| 2 h pain free: Zolmi (10.7%) > ASA + Met (5.3%) | |||
| Tfelt-Hansen et al., 1995 [65] | ASA 900+ Met / Suma 100 / Pl | 421 | Success rate 1st attack: ASA + Metocl (57%) = Sum (53%) > Pl (24%) |
| Diener et al., 2004 [76] | ASA 1000 / Suma 50 / Ibu 400/ Pl | 312 | 2 h relief : Ibu (60.2%) = Suma (55.8%) = ASA (52.5%) > Pl |
| 2 h pain free: Suma (37.1%) = Ibu (33.2%) > ASA (27.1%) > Pl (12.6%) | |||
| Diener et al., 1999 [66] | Lys-ASA 1000 iv / Suma 6 s.c. | 275 | 2 h relief: Suma (91%) > Lys-ASA (74%) > Pl (24%) |
| 2 h pain free: Suma (76.3%) > Lys-ASA (43.7%) > Pl (14.3%) | |||
| Misra et al., 2007 [76] | Ibu 400 / Riza 10 / Pl | 155 | 2 h relief: Riza (73%) > Ibu (54%) > Pl (8%) |
| Hämäläinen et al., 1997 [78] | Ibu 10/kg / Ace 15/kg / Pl (children 4–16 yo) | 88 | Ibu > Ace > Pl |
| Karachalios et al., 1992 [109] | Diclo 75 im / Ace im. | 86 | 30 min pain free: Dicl (88%) > Ace (17.5%) |
| Bussone et al., 1999 [94] | DicloK 50, 100 / Suma 100 / Pl | 156 | 2 h relief: DicloK 50 (-17) = Diclo 100 (-18.6) = Suma 100 (-14.5) > Pl |
| Schoenen et al., 2008 [99] | Aceclo 100 + Almo 12.5 / Almo 12.5 + Pl | 112 | 2 h relief: Aceclo + Almo (69%) > Almo + Pl (57.9%) |
| 2 h pain free: Aceclo + Almo (40.7%) > Almo + Pl (29.1%) | |||
| Hakkarainen et al., 1979 [84] | Tol 200 / Erg 1 / ASA 500 / Pl | 20 | Duration of attacks: Tol (3,2) = Erg (3,8) = ASA (4,2) > Pl (7,1) |
| Myllyla et al., 1998 [85] | Tol 200 / Suma 100 | 141 | 2 h response: Tol (77%) = Sum (79%) > Pl (29%) |
| Larsen et al., 1990 [63] | Tol 200,400 / Ace 500,1000 | 83 | 2 h effect on pain: Tol > Ace |
| Pradalier et al., 1985 [111] | Napro 825 / Erg 2+Caff 91.5+Cyclizine 50 | 114 | If taken within 2 h of onset: Napro > Erg + Caff + C |
| Treves et al., 1992 [112] | Napro / Erg | 42 | Overall patients' satisfaction: Napro > Erg |
| Duration and severity reduction: Napro = Erg | |||
| Sargent et al., 1988 [113] | Napro 825 / Erg 1+Caff 100 | Attack abortion: Napro = Erg + Caff > Pl | |
| Nausea reduction: Napro > Erg + Caff | |||
| Smith et al., 2005 [93] | NaproNa 500 / Suma 50 / NaproNa 500+Suma 50 / Pl | 972 | 2 h relief: NaproNa + Suma (65%) > Suma (49%) = NaproNa (46%) > Pl (27%) |
| 2 h pain free: NaproNa + Suma (34%) > Suma (20%) = NaproNa (18%) > Pl (6%) | |||
| Brandes et al., 2007 [91] | NaproNa 500 / Suma 85 / NaproNa 500+Suma 85 / Pl (2 studies) | 1461/1495 | 2 h relief: NaproNa + Suma (65/57%) > Suma (55/50%) > NaproNa (44/43%) > Pl (28/29%) |
| 2 h pain free: NaproNa + Suma (34/30%) > Suma (25/23%) = NaproNa (15/16%) > Pl (9/10%) | |||
| Kinnunen et al., 1988 [100] | Pirpro 200 (500) / Erg 2 (5) / Pl | 55 | Pain relief: Pirpro = Erg > Pl |
| Need for rescue medication: Pirpro(18/58) = Erg (18/59) < Pl (32/60) | |||
| Karabetsos et al., 1997 [103] | Keto 100 im / Ace 500 im | 64 | 40 min relief: Keto (82.5%) > ace (17.5%) |
| Dib et al., 2002 [102] | Keto 75, 150 / Zolmi 2,5 / Pl | 235 | 2 h relief: Zolmi (67%) = Keto 150 (62%) = Keto 75 (63%) > Pl |
| Larkin et al., 1992 [114] | Ketorolac 30 im / Meperidine 75 im | 31 | 1 h relief: Meperidine > Ketorolac |
| Davis et al., 1995 [115] | Ketorolac 60 im / Meperidine 75+ promethazine 25 im | 42 | 30 min response: Meperidine + promethazine (68%) = Ketorolac (55%) |
| Shrestha et al., 1996 [116] | Ketorolac 60 im / Chlorpromazine 25 iv | 47 | 30 min-2h relief: Ketorolac = Chlorpromazine |
| Seim et al., 1998 [117] | Ketorolac 30 iv / Prochlorperazine 10 iv | 64 | 1 h relief: Prochlorperazine > Ketorolac |
| Meredith et al., 2003 [118] | Ketorolac 30 iv / Suma 20 nasal | 29 | 1 h relief: Ketorolac > Suma |
| Sandrini et al., 2007 [119] | Indo 25+Prochlor 2+Caff 75 / Suma 50 | 297 | 2 h relief: I + P + C (57%) = Suma (57%) |
| 2 h pain free: I + P + C (32%) = Suma (36%) | |||
| Di Monda et al., 2003 [120] | Indo 25 + Prochlor 2 + Caff 75 rectal / Suma 25 rectal | 88 | 2 h relief: I + P + C (67%) = Suma (63%) |
| 2 h pain free: I + P + C (47%) > Sum (35%) |
Abbreviations: Ace: acetaminophen; Aceclo: aceclofenac; Almo: almotriptan; ASA: acetylsalicylic acid-aspirin; Caff: caffeine; Diclo: diclofenac; DicloK: diclofenac-potassium; Erg: ergotamine; Ibu: ibuprofen; Indo: indomethacin; Keto: ketoprofen; Met: metoclopramide; Napro: naproxen; NaproNa: naproxen-sodium; Pirpro: pirprofen; Suma: sumatriptan; Riza: rizatriptan; Tol: tolfenamic acid; Zolmi: zolmitriptan.