Table A1.

Genes down regulated in all HCV subjects compared to normal.

Gene ID	Name	Short name	Function
1554479_a_at	Caspase recruitment domain family, member 8	CARD8	Inhibits NF-kappa B activation. Suppression of apoptotic processes and inflammatory signaling pathways
203373_at	Suppressor of cytokine signaling 2	SOCS2	Negative regulator of apoptotic processes and cytokine signal transduction pathway
205798_at	Interleukin 7 receptor	IL7R	Involved in B cell and T cell proliferation and T cell development in thymus
205898_at	Chemokine (C-X3-C motif) receptor 1	CX3CR1	Mediates adhesion and migration of leukocytes such as monocytes, NK cells, and T lymphocytes
206978_at	Chemokine (C-C motif) receptor 2	CCR2	Monocyte chemotaxis
207269_at	Defensin, alpha 4, corticostatin	DEFA4	Expressed in the granule of neutrophils and has chemotactic and antimicrobial properties
217911_s_at	BCL2-associated athanogene 3	BAG3	Hsp70 co-chaperone and negative regulator of apoptosis. Also regulates development, cell motility, and autophagy
222201_s_at	CASP8 associated protein 2	CASP8AP2	Regulates apoptosis and cell cycle/survival
209728_at	Major histocompatibility complex, class II, DR beta 4	HLA-DRB4	Cell surface receptor that presents exogenous peptide antigens and is involved in T cell receptor signaling pathway
202018_s_at	Lactotransferrin /// similar to lactotransferrin	LOC728320 /// LTF	Glycoprotein that has antimicrobial and antiviral properties
205033_s_at	Defensin, alpha 1 /// defensin, alpha 3, neutrophil-specific /// defensin alpha 1	DEFA1 /// DEFA3 /// LOC653600 /// LOC728358	Expressed in the granule of neutrophils and has chemotactic and antimicrobial properties