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. 2010 Aug 26;3(9):2768–2798. doi: 10.3390/ph3092768

Figure 3.

Figure 3

Limited contribution of TRPA1, TRPV4, TRPV1 and ASIC3 to low-threshold afferent mechanosensitivity. TRPA1 deletion only reduces the responsiveness of (A) mucosal and (C) muscular/mucosal afferents to mucosal stroking and does not affect the stretch responses of (B) muscular or (C) muscular/mucosal afferents. Deletion of TRPV4 has no effect at all on low threshold afferent mechanosensitivity (A–C). Deletion of TRPV1 or ASIC3 markedly reduces the stretch response of (C) muscular/mucosal afferents. However,TRPV1 or ASIC3 deletion has no effect on mucosal or muscular afferent mechanosensitivity (A, B). TRPV4 modified from Brierley et al., [36] with permission. TRPA1 modified from Brierley et al., [35] with permission. TRPV1 and ASIC3 modified from Jones et al., [52] with permission.