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(A) CRL1, (B) CRL2, (C) CRL3, (D) CRL4, (E) CRL5, (F) CRL7, (G) CRL9. Representative and selective substrates of each individual CRL are shown, along with the biological processes they regulate. Note that substrates in red are tumor suppressors, whereas in green are oncoproteins. (The color version of the figure is available in the electronic copy of the article).
