Table1.

Quantity	Description
à (rS)REF	Time-integrated activity in source region, S, of a reference anatomical model
D(rT)REF	Absorbed dose to target region, T, of a reference anatomical model
wR and wT	Radiation and tissue-weighting factors, respectively
H (rT), E, and LAR	Equivalent dose to target region, T, of a reference model, effective dose to a reference model, and lifetime attributable risk, respectively
A(x,y,z,t), ρ(x,y,z,t), and Z(x,y,z,t)	Spatiotemporal map of the activity, tissue density, and tissue composition (atomic number [Z]-value), respectively
(x,y,z,t), D(x,y,z), and DVH(ν)	Absorbed dose-rate, absorbed dose, and dose-volume histogram for a patient-specific tissue volume, v, respectively
α and β	Tissue-specificcoefficients of radiation damage proportional to dose (single event is lethal) and dose squared (2 sublethal events required for lethal damage), respectively
μ and RBE	DNA repair rate assuming exponential repair of DNA damage, relative biological efficacy
BED, NTCP, and TCP	Biological effective dose, normal tissue complication probability, and tumor control probability, respectively