Table 1. Characteristics of population-based cohort of 43,722 1-year survivors of testicular cancer and risk of leukemia according to subtype*.
| All leukemia | AML | ALL | CML | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
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| Characteristic | No. of patients | Person-years of follow-up | No. | O/E (95%CI) | No. | O/E (95%CI) | No. | O/E (95%CI) | No. | O/E (95%CI) |
| All patients | 42,722 | 501,711 | 89 | 2.6 (2.1–3.2) | 53 | 3.1 (2.3–3.9) | 10 | 3.1 (1.5–5.4) | 16 | 1.7 (1.0–2.7) |
| GCT, seminoma | 23,840 | 287,000 | 55 | 2.3 (1.8–3.0) | 32 | 2.6 (1.8–3.7) | 6 | 3.2 (1.3–6.5) | 9 | 1.4 (0.7–2.6) |
| GCT, nonseminoma | 17,664 | 201,707 | 32 | 3.2 (2.2–4.5) | 20 | 4.2 (2.6–6.3) | 4 | 3.1 (1.0–7.2) | 6 | 2.2 (0.9–4.4) |
| Other/unspecified histology | 1,218 | 13,004 | 2 | 2.0 (0.3–6.3) | 1 | 2.1 (0.1–9.2) | 0 | — | 1 | 4.0 (0.2–17.6) |
| Age (yr) at testicular cancer diagnosis | ||||||||||
| <30 | 15,653 | 192,214 | 27 | 4.1 (2.8–5.9) | 20 | 6.8 (4.2–10.2) | 4 | 3.4 (1.1–7.9) | 1 | 0.5 (0.0–2.4) |
| 30–39 | 15,013 | 179,590 | 23 | 2.3 (1.5–3.4) | 10 | 2.0 (1.0–3.5) | 3 | 3.0 (0.8–7.9) | 8 | 2.8 (1.3–5.2) |
| ⩾40 | 12,056 | 129,906 | 39 | 2.2 (1.6–2.9) | 23 | 2.4 (1.6–3.6) | 3 | 2.7 (0.7–7.1) | 7 | 1.5 (0.7–3.0) |
| Calendar year of testicular cancer diagnosis | ||||||||||
| 1943–1974 | 6,638 | 139,251 | 30 | 2.2 (1.5–3.0) | 13 | 1.9 (1.0–3.1) | 4 | 4.4 (1.4–10.3) | 8 | 2.2 (1.0–4.2) |
| 1975–2002 | 36,084 | 362,459 | 59 | 2.8 (2.2–3.6) | 40 | 3.8 (2.8–5.1) | 6 | 2.5 (1.0–5.1) | 8 | 1.4 (0.6–2.6) |
| Initial treatment | ||||||||||
| Surgery only | 10,007 | 103,767 | 10 | 1.6 (0.8–2.9) | 9 | 2.8 (1.4–5.1) | 0 | — | 1 | 0.6 (0.0–2.7) |
| RT, no CT | 13,682 | 184,810 | 39 | 2.7 (1.9–3.6) | 20 | 2.5 (1.6–3.8) | 5 | 4.4 (1.6–9.4) | 8 | 2.1 (1.0–3.9) |
| CT, no RT | 5,283 | 48,333 | 8 | 3.9 (1.8–7.3) | 7 | 6.8 (2.9–13.2) | 0 | — | 0 | — |
| RT and CT | 842 | 8,785 | 2 | 4.5 (0.7–13.8) | 2 | 8.5 (1.4–26.3) | 0 | — | 0 | — |
| No, of patients entering follow-up interval | ||||||||||
| 1–4 yr | 42,722 | 146,814 | 32 | 4.8 (3.3–6.6) | 22 | 7.1 (4.6–10.6) | 5 | 5.5 (2.0–11.8) | 2 | 1.1 (0.2–3.3) |
| 5–9 yr | 32,157 | 137,261 | 18 | 2.5 (1.5–3.8) | 12 | 3.4 (1.8–5.7) | 1 | 1.2 (0.1–5.4) | 4 | 1.9 (0.6–4.5) |
| 10–14 yr | 23,053 | 94,868 | 13 | 2.1 (1.1–3.4) | 5 | 1.6 (0.6–3.4) | 2 | 3.4 (0.6–10.5) | 5 | 2.9 (1.0–6.2) |
| ⩾15 yr | 15,148 | 122,767 | 26 | 1.8 (1.2–2.6) | 14 | 1.8 (1.0–3.0) | 2 | 2.1 (0.4–6.6) | 5 | 14 (0.5–3.0) |
CI = confidence interval; GCT = germ cell tumor; RT = radiotherapy; CT = chemotherapy.
*
O = Observed number of cases; E = expected number of cases; O/E = observed-to-expected ratio