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. 2014 May 5;111(20):7421–7426. doi: 10.1073/pnas.1323599111

Fig. 5.

Fig. 5.

Gastrointestinal expression of cloned BSH in conventionally raised mice reduces weight gain, serum cholesterol, and liver triglycerides. (A) Average weight gain over time measured in grams following colonization of mice with EC or ECBSH1. Data represent antibiotic-treated mice (solid circles), EC-colonized mice (solid squares), and ECBSH1-colonized mice (solid triangles) with weight gain monitored over 10 wk. **P < 0.005 and ***P < 0.0005 for ECBSH1 mice relative to EC-colonized controls. (B) Weight of total excised fat from mice undergoing antibiotic treatment alone and mice colonized by EC, ECBSH1, or ECBSH2. *P < 0.05 relative to the EC-colonized control (n = 5 per group). (C) Levels of LDL cholesterol in plasma in mice colonized by EC, ECBSH1, or ECBSH2 and control uncolonized mice. *P < 0.05 relative to controls (n = 5 per group). (D) Levels of liver triglycerides in mice colonized by EC, ECBSH1, or ECBSH2 and in antibiotic-treated controls (Ab). *P < 0.05. (n = 5 per group). All analyses used the Student t test.