Fig. 5.

The origins of two subgroups of NG2 progenitors during development in relation to their final terminal cell fate and location. At E14.5, the first-wave (newly generated) NG2⁺ progenitor cells are located at the MGE. At E16.5, the E14.5-generated NG2⁺ interneuronal progenitors tangentially migrate out of the MGE progenitor zone toward the cortical marginal layer. At E18.5, the late embryonic/neonatal GFAP⁺ NPC-derived NG2⁺ OPCs appear at the lateral ganglionic eminence (dorsal VZ and SVZ). At P30, the mature NG2 derived interneurons reside within dorsal cortical deep layers. The mature NG2 derived OLs found in both gray and white matters.