Fig. 7.

Pharmacological inhibition of NF-κB reduces expression of IL-7Rα in human peripheral T cells. PBMCs from healthy individuals were cultured for 24 h with 10 ng/mL recombinant human IL-7, washed, and incubated for 24 h with increasing doses of NF-κBi. Expression of CD127 was assessed in CD3⁺CD4⁺CD45R0⁻ and CD3⁺CD8⁺CD45R0⁻ live-gated cells and represented compared with maximum (NF-κBi = 0 nM). Results are representative of two independent experiments.