Table 1.
Tolerated and deleterious nsSNPs using SIFT.
| S. No | rsID | Alleles | Position | AA change | Prediction | Score |
|---|---|---|---|---|---|---|
| 1 | rs121908314 | L/V | 371 | Leu/Val | Damaging | 0.04 |
| 2 | rs121908313 | F/L | 251 | Phe/Leu | Damaging | 0.01 |
| 3 | rs121908312 | K/N | 79 | Lys/Asn | Tolerated | 0.52 |
| 4 | rs121908311 | G/S | 377 | Gly/Ser | Damaging | 0.02 |
| 5 | rs121908310 | V/F | 398 | Val/Phe | Damaging | 0.01 |
| 6 | rs121908308 | R/G | 353 | Arg/Gly | Tolerated | 0.38 |
| 7 | rs121908307 | S/T | 364 | Ser/Thr | Tolerated | 0.12 |
| 8 | rs121908306 | C/G | 342 | Cys/Gly | Damaging | 0.01 |
| 9 | rs121908305 | G/R | 325 | Gly/Arg | Tolerated | 0.44 |
| 10 | rs121908304 | W/C | 312 | Trp/Cys | Damaging | 0.00 |
| 11 | rs121908303 | F/V | 216 | Phe/Val | Damaging | 0.00 |
| 12 | rs121908302 | V/L | 15 | Val/Leu | Tolerated | 0.07 |
| 13 | rs121908301 | G/S | 478 | Gly/Ser | Tolerated | 0.17 |
| 14 | rs121908300 | Y/H | 212 | Tyr/His | Damaging | 0.03 |
| 15 | rs121908299 | P/S | 122 | Pro/Ser | Tolerated | 0.37 |
| 16 | rs121908298 | P/L | 289 | Pro/Leu | Tolerated | 0.48 |
| 17 | rs121908297 | K/Q | 157 | Lys/Gln | Tolerated | 0.06 |
| 18 | rs121908295 | P/R | 415 | Pro/Arg | Damaging | 0.00 |
| 19 | rs80356773 | R/H | 496 | Arg/His | Tolerated | 0.19 |
| 20 | rs80356772 | R/H | 463 | Arg/His | Tolerated | 0.06 |
| 21 | rs80356771 | R/C | 463 | Arg/Cys | Damaging | 0.02 |
| 22 | rs80356769 | V/L | 394 | Val/Leu | Damaging | 0.03 |
| 23 | rs80356765 | A/T | 338 | Ala/Thr | Tolerated | 0.39 |
| 24 | rs80356763 | R/L | 131 | Arg/Leu | Tolerated | 0.24 |
| 25 | rs80205046 | P/L | 182 | Pro/Leu | Damaging | 0.00 |
| 26 | rs80116658 | G/D | 265 | Gly/Asp | Damaging | 0.00 |
| 27 | rs80020805 | M/I | 416 | Met/Ile | Tolerated | 0.42 |
| 28 | rs79945741 | F/L | 213 | Phe/Leu | Tolerated | 0.18 |
| 29 | rs79796061 | D/V | 127 | Asp/Val | Damaging | 0.00 |
| 30 | rs79696831 | R/H | 285 | Arg/His | Damaging | 0.00 |
| 31 | rs79653797 | R/Q | 120 | Arg/Gln | Damaging | 0.00 |
| 32 | rs79637617 | P/L | 122 | Pro/Leu | Damaging | 0.02 |
| 33 | rs79215220 | P/R | 266 | Pro/Arg | Damaging | 0.00 |
| 34 | rs79185870 | F/L | 417 | Phe/Leu | Damaging | 0.01 |
| 35 | rs78973108 | R/Q | 257 | Arg/Gln | Tolerated | 0.05 |
| 36 | rs78911246 | G/V | 189 | Gly/Val | Damaging | 0.02 |
| 37 | rs78802049 | D/E | 409 | Asp/Glu | Tolerated | 0.32 |
| 38 | rs78769774 | R/Q | 48 | Arg/Gln | Tolerated | 0.06 |
| 39 | rs78715199 | D/E | 380 | Asp/Glu | Damaging | 0.00 |
| 40 | rs78396650 | A/V | 309 | Ala/Val | Damaging | 0.00 |
| 41 | rs78198234 | H/R | 311 | His/Arg | Damaging | 0.00 |
| 42 | rs78188205 | A/D | 318 | Ala/Asp | Tolerated | 0.63 |
| 43 | rs77959976 | M/I | 123 | Met/Ile | Tolerated | 1.00 |
| 44 | rs77834747 | I/S | 119 | Ile/Ser | Tolerated | 0.34 |
| 45 | rs77829017 | G/E | 46 | Gly/Glu | Damaging | 0.01 |
| 46 | rs77738682 | N/I | 392 | Asn/Ile | Damaging | 0.00 |
| 47 | rs77451368 | G/E | 202 | Gly/Glu | Damaging | 0.02 |
| 48 | rs77369218 | D/V | 409 | Asp/Val | Tolerated | 0.06 |
| 49 | rs77321207 | Y/C | 395 | Tyr/Cys | Damaging | 0.00 |
| 50 | rs77284004 | D/A | 380 | Asp/Ala | Damaging | 0.00 |
| 51 | rs77035024 | F/L | 411 | Phe/Leu | Tolerated | 0.30 |
| 52 | rs77019233 | N/K | 117 | Asn/Lys | Tolerated | 0.21 |
| 53 | rs76910485 | P/L | 391 | Pro/Leu | Damaging | 0.00 |
| 54 | rs76763715 | N/S | 370 | Asn/Ser | Damaging | 0.05 |
| 55 | rs76763715 | N/T | 370 | Asn/Thr | Damaging | 0.04 |
| 56 | rs76539814 | T/I | 323 | Thr/Ile | Tolerated | 0.48 |
| 57 | rs76228122 | Y/C | 363 | Tyr/Cys | Damaging | 0.00 |
| 58 | rs76026102 | Y/C | 205 | Tyr/Cys | Damaging | 0.00 |
| 59 | rs76014919 | W/C | 378 | Trp/Cys | Damaging | 0.00 |
| 60 | rs75954905 | F/L | 37 | Phe/Leu | Tolerated | 0.30 |
| 61 | rs75671029 | D/N | 443 | Asp/Asn | Tolerated | 0.93 |
| 62 | rs75636769 | A/E | 190 | Ala/Glu | Tolerated | 1.00 |
| 63 | rs75564605 | I/T | 402 | Ile/Thr | Damaging | 0.04 |
| 64 | rs75548401 | T/M | 369 | Thr/Met | Tolerated | 0.08 |
| 65 | rs75528494 | S/R | 366 | Ser/Arg | Damaging | 0.03 |
| 66 | rs75385858 | N/T | 396 | Asn/Thr | Damaging | 0.00 |
| 67 | rs75243000 | F/S | 397 | Phe/Ser | Damaging | 0.02 |
| 68 | rs75090908 | D/E | 399 | Asp/Glu | Tolerated | 0.17 |
| 69 | rs74979486 | R/Q | 359 | Arg/Gln | Tolerated | 0.05 |
| 70 | rs74953658 | D/E | 24 | Asp/Glu | Damaging | 0.01 |
| 71 | rs74752878 | Y/C | 418 | Tyr/Cys | Damaging | 0.00 |
| 72 | rs74731340 | S/N | 271 | Ser/Asn | Tolerated | 0.26 |
| 73 | rs74598136 | P/L | 401 | Pro/Leu | Damaging | 0.00 |
| 74 | rs74500255 | F/Y | 216 | Phe/Tyr | Tolerated | 0.34 |
| 75 | rs74462743 | G/E | 195 | Gly/Glu | Damaging | 0.00 |
| 76 | rs61748906 | W/R | 184 | Trp/Arg | Damaging | 0.00 |
| 77 | rs11558184 | R/Q | 353 | Arg/Gln | Tolerated | 0.59 |
| 78 | rs2230288 | E/K | 326 | Glu/Lys | Tolerated | 0.86 |
| 79 | rs1141820 | H/R | 60 | His/Arg | Tolerated | 0.54 |
| 80 | rs1141818 | H/Y | 60 | His/Tyr | Tolerated | 0.09 |
| 81 | rs1141815 | M/T | 53 | Met/Thr | Tolerated | 0.59 |
| 82 | rs1141814 | R/W | 48 | Arg/Trp | Damaging | 0.00 |
| 83 | rs1141812 | R/S | 44 | Arg/Ser | Tolerated | 0.14 |
| 84 | rs1141811 | T/I | 43 | Thr/Ile | Damaging | 0.01 |
| 85 | rs1141811 | T/R | 43 | Thr/Arg | Damaging | 0.02 |
| 86 | rs1141808 | E/K | 41 | Glu/Lys | Tolerated | 0.52 |
| 87 | rs1141804 | S/G | 16 | Ser/Gly | Tolerated | 1.00 |
| 88 | rs1141802 | L/S | 15 | Leu/Ser | Tolerated | 0.63 |
| 89 | rs1064651 | D/H | 409 | Asp/His | Tolerated | 0.05 |
| 90 | rs1064648 | R/H | 329 | Arg/His | Tolerated | 0.17 |
| 91 | rs1064644 | S/P | 196 | Ser/Pro | Tolerated | 0.17 |
| 92 | rs421016 | L/P | 444 | Leu/Pro | Damaging | 0.00 |
| 93 | rs381737 | F/I | 213 | Phe/Ile | Tolerated | 0.18 |
| 94 | rs381427 | V/E | 191 | Val/Glu | Tolerated | 0.16 |
| 95 | rs381427 | V/G | 191 | Val/Gly | Tolerated | 0.16 |
| 96 | rs368060 | A/P | 456 | Ala/Pro | Tolerated | 0.09 |
| 97 | rs364897 | N/S | 188 | Asn/Ser | Tolerated | 0.17 |
The consensus SNPs are shown in bold.