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. 2014 May 27;8:129. doi: 10.3389/fnins.2014.00129

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Copyright © 2014 Blednov, Benavidez, Black and Harris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PDE3 and PDE5 inhibitors do not alter alcohol intake during the first 6 h of the 24-h two-bottle choice paradigm. Ethanol consumption is presented as g/kg/6 h: (A) Milrinone (D) Olprinone (G) Zaprinast. Preference for ethanol: (B) Milrinone (E) Olprinone (H) Zaprinast. Total fluid intake (g/kg/6 h): (C) Milrinone (F) Olprinone (I) Zaprinast. Data were analyzed by Two-Way ANOVA with repeated measures followed by Bonferroni's test for multiple comparisons (n = 6 per group; EtOH = ethanol).