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. Author manuscript; available in PMC: 2014 May 27.
Published in final edited form as: JOP. 2011 Jul 8;12(4):322–324.

Table 1.

Genetic syndromes associated with pancreatic cancer.

Syndrome Associated most common other
malignancy		 Estimated increased risk of
pancreatic adenocarcinoma (fold)
Peutz-Jeghers syndrome (STK11) Colorectal cancer, stomach, breast, ovarian 132
Hereditary pancreatitis - 50 to 67
Familial atypical multiple mole melanoma (FAMMM; p16) Melanoma, head/neck 13 to 39
Hereditary nonpolyposis colorectal cancer (HNPCC; MSI) Colorectal cancer, endometrial, ovarian 8.6
Familial adenomatous polyposis (FAP; Apc) Colorectal cancer, duodenal, thyroid 4.5
Breast and ovarian cancer syndrome (BRCA 1/2) Breast, ovarian 2–3 to 9

Apc: adenomatous polyposis coli gene; MSI: microsattelite instability