Table 1.

Significant activations revealed by whole brain (WB) and regions of interest (ROI) analysis for contrast CS+ > CS− during early extinction.

Group	Brain structure	x	y	z	Z	Cluster size	P
Delay	Cuneus R (WB)	12	−76	24	3.7	29	<0.001
	Precentral gyrus L (WB)	−22	−14	62	3.67	26	<0.001
	Caudate body L (WB)	−18	20	8	3.53	7	<0.001
	Medial orbital frontal gyrus R (WB)	12	58	−12	3.43	5	<0.001
	Middle occipital gyrus L (WB)	−34	−66	18	3.32	7	<0.001
	Insula R (ROI)	44	2	0	3.01	10	0.001
	Caudate L (ROI)	−18	20	8	3.53	17	<0.001
	Putamen R (ROI)	36	−12	−8	3.07	14	<0.001
	Medial orbital frontal gyrus R (ROI)	12	58	−12	3.43	11	<0.001
Trace	Postcentral gyrus L (WB)	−42	−32	54	4.7	6	<0.001
	Rolandic operculum R (WB)	42	−22	26	4.37	86	<0.001
	Putamen L (WB)	−30	−14	2	4.11	8	<0.001
	Calcarine R (WB)	12	−92	12	4.09	19	<0.001
	Middle frontal gyrus R (WB)	40	6	40	3.55	7	<0.001
	Ventral ACC L (WB)	−12	10	30	3.55	8	<0.001
	Insula R (ROI)	36	−18	22	3.78	15	<0.001
	Dorsal ACC R (ROI)	4	22	34	2.93	11	0.002
	Putamen L (ROI)	−30	−14	2	4.11	14	<0.001
	Middle frontal gyrus R (ROI)	40	6	40	3.55	12	<0.001

α < 0.001 uncorrected for whole brain analysis (WB) and α < 0.005, uncorrected ROI analyses, with a minimum cluster size of k = 5 (WB) or k = 10 (ROI); L, left; R, right hemisphere. The cluster with the largest number of significant voxels within each region is reported. Coordinates x, y, and z of the peak voxels are given in Montreal Neurological Institute space.