Table 2. Allele Frequency in All Cohorts.
| SNP rs2010795 | n | AA | f(AA) | AG | f(AG) | GG | f(GG) | MAF (A) | Allelic p | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| German | 0.00032 | 1.319 (1.134–1.534) | ||||||||
| German PD | 676 | 77 | 0.11 | 294 | 0.43 | 305 | 0.45 | 0.33 | ||
| KORA | 485 | 29 | 0.06 | 192 | 0.40 | 264 | 0.54 | 0.26 | ||
| POPGEN | 487 | 33 | 0.07 | 215 | 0.44 | 239 | 0.49 | 0.29 | ||
| All German controls | 972 | 62 | 0.06 | 407 | 0.42 | 503 | 0.52 | 0.27 | ||
| British | 0.02815 | 1.286 | (1.027–1.610) | |||||||
| British PD | 203 | 24 | 0.12 | 90 | 0.44 | 89 | 0.44 | 0.34 | ||
| British controls | 142 | 15 | 0.11 | 46 | 0.32 | 81 | 0.57 | 0.27 | ||
| ORCADES | 483 | 27 | 0.06 | 200 | 0.41 | 256 | 0.53 | 0.26 | ||
| SOCCS | 501 | 43 | 0.08 | 228 | 0.46 | 230 | 0.46 | 0.31 | ||
| All UK controls | 1126 | 85 | 0.08 | 474 | 0.42 | 567 | 0.50 | 0.29 | ||
| Italian | 0.00252 | 1.346 | (1.110–1.632) | |||||||
| Italian PD | 353 | 47 | 0.13 | 154 | 0.44 | 152 | 0.43 | 0.35 | ||
| Italian controls | 172 | 18 | 0.10 | 69 | 0.40 | 85 | 0.49 | 0.31 | ||
| Val Borbera | 532 | 40 | 0.08 | 219 | 0.41 | 273 | 0.51 | 0.28 | ||
| All Italian controls | 704 | 58 | 0.08 | 288 | 0.41 | 358 | 0.51 | 0.29 | ||
| Combined analysis | 1.18E–07 | 1.304 (1.178–1.444) | ||||||||
| All PD | 1232 | 148 | 0.12 | 538 | 0.44 | 546 | 0.44 | 0.34 | ||
| All controls | 2802 | 205 | 0.07 | 1169 | 0.42 | 1428 | 0.51 | 0.28 |
SNP = single-nucleotide polymorphism; OR = odds ratio; CI = confidence interval; MAF = minor allele frequency; PD = Parkinson’s disease; KORA = Kooperative Gesundheits forschung in der Region Augsburg; POPGEN = Populations genetisches Forschungsprojekt des Nationalen; ORCADES = Orkney Complex Disease Study; SOCCS = Study of Colon Cancer Survivors.