Figure 3. Structure of the Slo channels and their regulation by pyridine nucleotides.

Organization of the structural subunits of Slo1 (A) and Slo 2 family of channels (B). Adapted with permission from Nat Rev Neurosci, Salkoff et al.¹³C, Inside-out patch-clamp recordings from pulmonary artery smooth muscle cells; horizontal bars represent application of 2 mmol/L NADH or NAD⁺. Current was recorded with a holding potential of +50 mV. Reprinted with permission from Exp Physiol, Park et al¹³⁰; D, Inside-out patch-clamp recordings from rat dorsal root ganglion neurons in the absence and presence of 1 mmol/L NAD⁺ made from a holding potential of −80 mV. Adapted with permission from J Neurosci, Tamsett et al¹² (Illustration: Ben Smith).