Table 1.
Clock gene | Mouse | Human | ||
---|---|---|---|---|
Fibroblast | Monocyte | |||
NIH3T3 | OA-FLS | RA-FLS | THP-1 | |
Bmal1 | Not affected | — | Up | Up |
Clock | Slightly up | — | Slightly up | Not affected |
Per1 | Down (early~3 h: up) | Not affected | Slightly up | Slightly up |
Per2 | Down | — | Down | Down |
Per3 | Down | Down | — | — |
Cry1 | Up | — | Up | Down |
Cry2 | Slightly down | — | Not affected | Up |
Dbp | Down | Down | Down | — |
Tef | Down | — | Down | — |
Hlf | Down | — | Down | — |
E4BP4 | — | — | Up | — |
Re v-erbα | Slightly up | — | — | Down |
*Based on results of the refer 49–53. — denotes no data. OA-FLS: osteoarthritis fibroblast-like synovial cells. RA-FLS: rheumatoid arthritis fibroblast-like synovial cells.