Table 2.

Risk Tolerance of IBS Patients to Achieve Symptom Relief if Treated with a New Medication

	Death		Serious or Permanent Adverse Events		Mild Adverse Events
	All (N=1966)	Severe IBS (N=400)	All (N=1966)	Severe IBS (N=400)	All (N=1966)	Severe IBS (N=400)
Acceptable Patient Risk for Total IBS Symptom Relief:	%	%	%	%	%	%
Would Not Take	30.2	21.3	39.6	32.8	8.8	5
1/10 million	15.4	13.5	16.3	14	7.3	9
1/1 million	17.6	15.8	17.2	15.3	7.3	4
1/100,000	14.5	14.5	9.9	12	9.5	6.3
1 in 10,000	8.9	10.3	6.9	7.3	11.9	10.8
1 in 1,000	5.8	10	4.5	7.5	14.5	13.8
1 in 100	4.2	6.3	2.6	4.3	14.3	14.5
1 in 10	1.5	3	1.3	3	9.1	11
1 in 5	0.9	2	0.7	1.5	4.2	4.8
1 in 3	0.2	0.3	0.2	0.5	1.9	2
1 in 2	1.1	3.3	0.8	2	11.3	19

IBS, irritable bowel syndrome.

Adapted from Drossman DA et al. J Clin Gastroenterol. 2009;43(6):541-550.²²