Table 1.

Main inflammatory pathways influenced by curcumin activity.

Chronic disease	Major mediators involved
Arthritis	COX, MMPs, STAT3, NF-κB
Scleroderma	MAP kinase, NF-κB, TGIF
Psoriasis	STAT3, NF-κB, Bcl-xL, IAPs
Allergies and asthma	MAP kinase, NF-κB
Diabetes	PPAR-γ, NOS
Obesity	TNF-α, IL-6, Wint/β-catenin
Neuropathies	IL-1β, VEGF, NF-κB, TNF-α, NO, LRRK2
Cardiopathies	Bcl-2, IL-6, Caspase, NF-κB, TNF-α
Renal ischemia	HSP-70, MAP kinase, NF-κB, TNF-α