Table 3.
Main and interaction effects of WMH, GA, and MTA in relation to the different cognitive domain scores.
| Global cognition | Episodic memory | Working memory | Executive function | Psychomotor speed | |
|---|---|---|---|---|---|
| Step 1 | |||||
| GA (β) | -0.140** | -0.108* | -0.062 | -0.187*** | -0.199** |
| Step 2 | |||||
| GA (β) | -0.077 | -0.060 | -0.046 | -0.154** | -0.096 |
| MTA (β) | -0.140** | -0.153** | -0.050 | -0.116* | -0.238*** |
| WMH (β) | -0.081 | -0.007 | -0.001 | 0.012 | -0.072 |
| Step 3 | |||||
| GA(β) | -0.080 | -0.064 | -0.045 | -0.157** | -0.096 |
| MTA (β) | -0.242*** | -0.292*** | -0.150 | -0.219** | -0.202* |
| WMH (β) | -0.165* | -0.121 | -0.086 | -0.073 | -0.045 |
| MTAxWMH (β) | 0.175 | 0.238* | 0.173 | 0.177 | -0.060 |
| Step 3 | |||||
| GA(β) | -0.090 | -0.268** | -0.165 | -0.348*** | -0.059 |
| MTA (β) | -0.140** | -0.148** | -0.043 | -0.112* | -0.240** |
| WMH (β) | -0.086 | -0.086 | -0.047 | -0.062 | -0.059 |
| GAxWMH (β) | 0.017 | 0.275** | 0.157 | 0.256* | -0.048 |
| Step 3 | |||||
| GA(β) | -0.171 | -0.243** | -0.164 | -0.255** | -0.010 |
| MTA (β) | -0.179** | -0.229*** | -0.096 | -0.158* | -0.206** |
| WMH (β) | -0.078 | -0.002 | 0.005 | 0.014 | -0.077 |
| MTAxGA (β) | 0.128 | 0.251* | 0.158 | 0.137 | -0.115 |
Results of the hierarchical regression analyses with forced entry. For each cognitive domain, three analyses were performed, one for each interaction term. A higher cognitive score represents better task performance. GA: global atrophy; MTA: medial temporal atrophy; WMH: white matter hyperintensities. *p < 0.05, **p < 0.01, ***p < 0.001.